Επιστημονικά άρθρα

Immune checkpoint molecules. Possible future therapeutic implications in autoimmune diseases

Authors: Huang C, Zhu HX, Yao Y, Bian ZH, Zheng YJ, Li L, Moutsopoulos HM, Gershwin ME, Lian ZX Abstract: During host immune response, an initial and sufficient activation is required to avoid infection and cancer, yet an excessive activation bears the risk of autoimmune reactivity and disease development. This fastidious balance of the immune system is regulated by co-stimulatory and co-inhibitory molecules,…

Rheumatoid Arthritis Treatment. A Back to the Drawing Board Project or High Expectations for Low Unmet Needs?

Drosos AA, Pelechas E, Voulgari PV J. Clin. Med.2019, 8(8), 1237; https://doi.org/10.3390/jcm8081237Received: 5 July 2019 / Accepted: 15 August 2019 / Published: 16 August 2019 (Section Immunology) Abstract Despite the significant progress in Rheumatoid Arthritis (RA) therapeutics, there are several reports in the literature claiming that the size of unmet needs in RA is large. In the era before biologics,…

The role of dynamic susceptibility contrast perfusion- weighted MRI in the estimation of IDH mutation in gliomas

Sotirios Bisdas, Eser Sanverdi, Carole Sudre, Diana Roettger, Sebastian Brandner, Vasileios Katsaros; University College London, London, United Kingdom; IAG, London, United Kingdom Background: The presence of mutation in the encoding gene of isocitrate-dehydrogenase (IDH) has been defined as a molecular biomarker in the diagnosis and differentiation of gliomas. Dynamic Susceptibility Contrast Perfusion- Weighted Imaging (DSC…

Primary versus Secondary Sjögren Syndrome: Is It Time To Reconsider These Terms?

CLIO P. MAVRAGANI and HARALAMPOS M. MOUTSOPOULOS The Journal of Rheumatology July 2019, 46 (7) 665-666; DOI: https://doi.org/10.3899/jrheum.180392 Classification of systemic autoimmune diseases on the basis of clinical, serological, and genetic characteristics has long been considered a necessary approach to determine disease prognosis and institute appropriate therapeutic strategies1. Has this, however, truly been pursued by the scientific community? Probably not, because similar…