Επιστημονικά άρθρα

Cost-Effectiveness Analysis of Erenumab Versus OnabotulinumtoxinA for Patients With Chronic Migraine Attacks in Greece

Authors: Theodoros V Giannouchos, Dimos-Dimitrios Mitsikostas, Robert L Ohsfeldt, Athanassios Vozikis, Paraskevi Koufopoulou  Background: Migraine is a common, chronic neurovascular brain disorder with non-negligible multifaceted economic costs. Existing preventive treatments involve the selective use of onabotulinumtoxinA, which aims at migraine morbidity reduction for patients who have failed initial preventive treatment with oral agents. Erenumab is a new preventive treatment for…

Hypovitaminosis D in Healthy Pregnant Women and Their Newborns in Greece

Authors: Vasiliki Sideri, George Antonakos, Andreas Fretzayas , Achilleas Attilakos, Charalambos Chrelias, Vasiliki Papaevangelou, Polyxeni Nicolaidou, Anna Papadopoulou Background/objectives: The aim of this work was to evaluate the current vitamin D status in healthy pregnant women and their newborns living in Greece and assess possible associations between 25(OH)D and anthropometric features of their fetuses and newborns. Materials & methods: 81 healthy women were monitored during…

Chronic Venous Disease: From Symptoms to Microcirculation

Authors: Bernardo Senra Barros, Stavros K Kakkos, Marianne De Maeseneer , Andrew N Nicolaides The recently published European Venous Forum (EVF) Guidelines 2018 update on the management of chronic venous disorders of the lower limbs has focused on several new aspects: a new place for early symptoms, new data on microcirculation alterations, and a re-evaluation of veno-active drugs (VADs),…

The Greek (Hellenic) Rheumatology Over the Years: From Ancient to Modern Times

Authors: Lazaros I Sakkas, Panagiotis Tronzas Rheumatology has its roots in ancient Greece. Hippocrates and other prominent Greek (Hellenes) physicians in ancient times, Hellenistic, Roman, and Byzantine period were acute observers of disease course and of patients and were able to define many disorders. They wrote books on various aspects of medicine and these writings were…

Antimicrobial Overuse and Misuse in the Community in Greece and Link to Antimicrobial Resistance Using Methicillin-Resistant S. Aureus as an Example

Authors: Stamatis Karakonstantis, Dimitra Kalemaki Both antimicrobial consumption and antimicrobial resistance are very high in Greece, ranking among the highest of Europe. The link between antimicrobial consumption and resistance is well-known. Here, we discuss the reasons of antimicrobial overuse in Greece in the community (such as self-medication, dispersion of antibiotics by pharmacies without prescription, over-prescription by…

ΑΝΤΙΜΕΤΩΠΙΣΗ ΤΗΣ ΒΑΡΕΙΑΣ ΟΣΤΕΟΑΡΘΡΙΤΙΔΑΣ ΓΟΝΑΤΟΣ ΚΑΙ ΙΣΧΙΟΥ ΜΕ ΡΑΔΙΟΣΥΧΝΟΤΗΤΕΣ (ΘΕΡΜΟΚΑΥΤΗΡΙΑΣΜΟΣ)

ΑΝΤΙΜΕΤΩΠΙΣΗ ΤΗΣ ΒΑΡΕΙΑΣ ΟΣΤΕΟΑΡΘΡΙΤΙΔΑΣ ΓΟΝΑΤΟΣ ΚΑΙ ΙΣΧΙΟΥ ΜΕ ΡΑΔΙΟΣΥΧΝΟΤΗΤΕΣ (ΘΕΡΜΟΚΑΥΤΗΡΙΑΣΜΟΣ) Δ. ΓΟΥΛΕΣ, Δ. ΤΖΩΡΤΖΗΣ, ΤΡ. ΔΗΜΟΥ, Κ. ΚΟΚΚΙΝΗΣ ΟΜΑΔΑ ΙΑΤΡΩΝ ΚΑΙ ΣΥΝΕΡΓΑΤΩΝ ΕΕΛΙΑ Η οστεοαρθρίτις (ΟΑ) είναι μία χρόνια, εξελικτική, εκφυλιστική και φλεγμονώδης νόσος των κινητών αρθρώσεων, πολυπαραγοντικής αιτιολογίας, της οποίας η συχνότητα αυξάνεται με την ηλικία. Χαρακτηρίζεται από προϊούσα εκφύλιση και καταστροφή  του χόνδρου…

Ισχαιμικό Αγγειακό Εγκεφαλικό Επεισόδιο: Μηχανική Θρομβεκτομή – M. Καρύγιαννης

Μηχανική Θρομβεκτομή: Μια από τις σημαντικότερες εξελίξεις στην ιατρική τα τελευταία έτη Μιχάλης Καρύγιαννης Επεμβατικός Ακτινολόγος/Νευροακτινολόγος Ιατρικό Κέντρο Αθηνών Tα αγγειακά εγκεφαλικά επεισόδια (ΑΕΕ) αποτελούν τη δεύτερη συχνότερη αιτία θανάτου παγκοσμίως (11.8%) μετά την ισχαιμική καρδιακή νόσο και την τρίτη συχνότερη αιτία αναπηρίας (1). Στην Ελλάδα, πολύ πρόσφατα δεδομένα από την μελέτη – καταγραφή του…

Immune checkpoint molecules. Possible future therapeutic implications in autoimmune diseases

Authors: Huang C, Zhu HX, Yao Y, Bian ZH, Zheng YJ, Li L, Moutsopoulos HM, Gershwin ME, Lian ZX Abstract: During host immune response, an initial and sufficient activation is required to avoid infection and cancer, yet an excessive activation bears the risk of autoimmune reactivity and disease development. This fastidious balance of the immune system is regulated by co-stimulatory and co-inhibitory molecules,…